You are here

Photo: James C. Karegeannes, M.D.
Verified Patient Rating: 5 (528 patient reviews and ratings)

Additional Patient Reviews

To view more patient reviews and ratings for Dr. Karegeannes, please click below.
Hip, Joint Replacement, Knee

Dr. James C. Karegeannes [Care-ah-gene-us] graduated magna cum laude from the University of South Carolina Honors Program. In addition to being named a National Merit Scholar, he was also a member of Phi Beta Kappa. He completed medical school at Duke University and finished his internship at the San Diego Naval Hospital. This was followed by three years as a submarine and diving medical officer in the Navy. He then returned to Duke University for his orthopedic surgery training followed by a hip and knee replacement fellowship at Hospital for Special Surgery in New York City.

Dr. Karegeannes specializes in hip and knee replacement surgery and revision surgery for failed replacements as well as performs more than 450 joint replacement surgeries a year. He was named one of the “Top Doctors” for hip and knee arthroplasty in Money magazine’s, Special Report, “The Best Health Care in America,” in fall 2003.

He is active in local and national joint replacement organizations to help ensure that patients in our region can access the latest treatment options. He does not accept consulting fees or other payments from joint implant manufacturers to ensure his recommendations for treatment are unbiased and to place his patients’ interests first.

Outside the office, he enjoys spending time with his wife, two adult children, and one large hound dog. He serves on the local Boy Scout council executive board as well as enjoys hiking, gardening, and burrowing into old books about food and drink culture.

Education & Training

  • Bachelor of Science in Biology: University of South Carolina, Columbia, 1985, Magna Cum Laude
  • Doctor of Medicine: Duke University School of Medicine, Durham, North Carolina, 1989
  • General Surgery Internship: Naval Medical Center San Diego, San Diego, California, 1989 - 1990
  • Orthopedic Surgery Residency: Duke Health, Durham, North Carolina, 1994 - 1997
  • Adult Reconstruction Fellowship (Hip & Knee Replacement): Carolina Orthopaedic Center, Greenville, South Carolina, 1998
  • Adult Reconstruction Fellowship (Hip & Knee Replacement): The Hospital for Special Surgery, New York, New York, 1998 - 1999

Military Service

  • Honorable Discharge as Lieutenant Commander, Medical Corp, U.S. Navy Reserve, July 1997
  • Medical Officer, Submarine Squadron Six, Norfolk, Virginia, June 1991 - June 1993
  • Diving Medical Officer, USS John Marshall (SSN 611) Special Warfare Detachment, January - June 1991

Certification & Licensure

  • Fellow, American Association of Hip and Knee Surgeons, 2005
  • Fellow, American Academy of Orthopaedic Surgeons, February 2003
  • Board Certification: American Board of Orthopaedic Surgery, September 2001
  • U.S. Navy Submarine Medical Officer, December 1992
  • U.S. Navy Diving Medical Officer, December 1991
  • Licensure: State of North Carolina, State of South Carolina, Commonwealth of Virginia

Professional Memberships

  • American Association of Hip and Knee Surgeons
  • American Medical Association
  • American Academy of Orthopaedic Surgery
  • North Carolina Orthopaedic Association
  • Piedmont Orthopaedic Association


  • Piedmont Orthopaedic Foundation Research Grant, 1995: "Hyperbaric oxygen therapy for muscle strain injury."


  • Karegeannes JC. Ask A Doctor: Violent femur injuries can be painful, difficult to repair. Asheville Citizen-Times. June 1, 2004, H3.
  • Karegeannes JC, Windsor RE. "Osteotomies of the Knee for Arthritis." In Chapman's Operative Orthopaedics, Third Edition, edited by M. W. Chapman, et. al. Philadelphia: Lippincott Williams and Wilkins, 2001.
  • Karegeannes JC. Bony outgrowths of the temporal bone in United States Navy divers. Undersea Hyperbaric Med 1995; 12(3):301-306.
  • Karegeannes JC. External auditory canal exostoses in United States Navy divers. Undersea Medical Officer Thesis, Navy Undersea Medical Institute, Groton, CT, 1992.
  • Karegeannes JC. Alkaline phosphatase expression in lithium chloride treated sea urchin embryos. Honors Thesis, University of South Carolina , 1985.


  • Karegeannes JC. Ask A Doctor: A combionation of physical therapy, medications can ease bursitis. Asheville Citizen-Times. Dec 12, 2005 , H3.

Scientific Presentations

  • "Hyperbaric oxygen therapy for muscle strain injury." AOA Resident's Conference, Columbia University, New York, NY 1997.
  • "Knee flexion-closure position following total knee arthroplasty" North Carolina Orthopaedic Association Annual Meeting, Myrtle Beach, SC 1996.
  • "Thrombin inhibitory activity and in vivo clearance of polyethylene glycol - hirudin complex" Nineteenth annual Alpha Omega Alpha symposium, Duke University Medical Center . April 12, 1988 .

Honors & Awards

  • Unit Leader (Scoutmaster) Award of Merit – Troop 91, 2017
  • Baden Powell Fellow, World Organization of the Scout Movement, 2016
  • "Top Doctors" for Hip and Knee Arthroplasty, Money magazine, Special Report, "The Best Health Care in America", Fall 2003
  • Navy Commendation Medal, United States Navy, 1993
  • Navy Achievement Medal, United States Navy, 1991
  • Health Professions Scholarship, United States Navy, 1986 - 1989
  • Outstanding Seniors Award, University of South Carolina, 1985
  • Phi Beta Kappa, 1984
  • University of South Carolina General Scholarship, 1981 - 1985
  • University of South Carolina Alumni Association Scholarship, 1981 - 1985
  • National Merit Scholar, 1981 – 1985

Hospital Privileges 

  • Mission Hospitals Health System
“A perfect left hip replacement. Never any problems. He is the best in his field. I highly recommend him.”
– Arnold A.
Patient Rating: