James C. Karegeannes, M.D.


Dr. James C. Karegeannes [Care-ah-gene-us] graduated magna cum laude from the honors program of the University of South Carolina. He was a National Merit Scholar & Phi Beta Kappa. He received his medical degree from Duke Medical School in Durham, NC. He completed his internship at the San Diego Naval Hospital then returned to Duke for his residency in orthopaedic surgery. He completed an Adult Reconstruction Fellowship at The Hospital for Special Surgery in New York, NY.

Dr. Jim Karegeannes specializes in hip and knee replacement surgery as well as more complex revision surgery for failed replacements. Dr. Karegeannes performs over 450 joint replacement operations in an average year. He is active in local and national joint replacement organizations to insure that patients in our region have access to the latest treatment options. He reviews articles for publication in the Journal of Arthroplasty. He does not accept consulting fees or other payments from joint implant manufactures, rather he is paid by his patients.

In his free time Dr. Karegeannes enjoys being outdoors spending time with his wife, two children and two dogs. He serves as an Assistant Scoutmaster with Boy Scout Troop 91 in Asheville and on the Executive Board of the local Scout Council. He has had to call on his orthopedic training to help sustain himself as he takes up backpacking after a 30 year break.


  • Honorable Discharge as Lieutenant Commander, Medical Corp, U.S. Navy Reserve, July 1997.
  • Medical Officer, Submarine Squadron Six, Norfolk, VA June 1991 to June 1993.
  • Diving Medical Officer, USS John Marshall (SSN 611) Special Warfare Detachment, January to June 1991.
  • Attending physician, Blue Ridge Bone & Joint, Asheville, NC, August 1999 to present.
  • Divers Alert Network, Physician-on-call, Durham, NC March 1995 to December 1997.
  • Duke University, School of Medicine, Durham, NC; M.D., May 1989.
  • The University of South Carolina at Columbia; B.S. - Biology, magna cum laude, with Honors from South Carolina College (the honors college), May 1985.


  • Adult Reconstruction Fellowship (Hip & Knee Replacement), The Hospital for Special Surgery, New York, NY, August 1998 to July 1999.
  • Adult Reconstruction Fellowship (Hip & Knee Replacement), Carolina Orthopaedic Center, Greenville, SC, January 1998 to June 1998.
  • Resident, Division of Orthopaedics; Duke University Medical Center, January 1994 to December 1997.
  • Junior Assistant Resident, Department of General and Thoracic Surgery; Duke University Medical Center, July 1993 to December 1994.
  • Undersea Medical Officer Course; Naval Undersea Medical Institute, Groton, CT July to Dec. 1990.
  • Basic Surgery Internship; Naval Hospital San Diego, July 1989 to June 1990.
  • Piedmont Orthopaedic Foundation Research Grant, 1995: "Hyperbaric oxygen therapy for muscle strain injury."
  • Thomas Pace, James C. Karegeannes, M. Jason Palmer, Stephanie L. Tanner and Rebecca G. Snider. Press Fit Total Hip Prosthetic Stem: Ten Year Follow-up of the “Natural Hip” Femoral Stem," Advances in Orthopedics, 2014
  • Karegeannes JC. Ask A Doctor: Violent femur injuries can be painful, difficult to repair. Asheville Citizen-Times. June 1, 2004 , H3.
  • Karegeannes JC, Windsor RE. "Osteotomies of the Knee for Arthritis." In Chapman's Operative Orthopaedics, Third Edition , edited by M. W. Chapman, et. al. Philadelphia : Lippincott Williams and Wilkins, 2001.
  • Karegeannes JC. Bony outgrowths of the temporal bone in United States Navy divers. Undersea Hyperbaric Med 1995; 12(3):301-306.
  • Karegeannes JC. External auditory canal exostoses in United States Navy divers. Undersea Medical Officer Thesis, Navy Undersea Medical Institute, Groton, CT, 1992.
  • Karegeannes JC. Alkaline phosphatase expression in lithium chloride treated sea urchin embryos. Honors Thesis, University of South Carolina , 1985.


  • Karegeannes JC. Ask A Doctor: A combionation of physical therapy, medications can ease bursitis. Asheville Citizen-Times. Dec 12, 2005 , H3.
  • American Association of Hip and Knee Surgeons
  • American Medical Association
  • American Academy of Orthopaedic Surgery
  • North Carolina Orthopaedic Association
  • Piedmont Orthopaedic Association
  • "Hyperbaric oxygen therapy for muscle strain injury." AOA Resident's Conference, Columbia University, New York, NY 1997.
  • "Knee flexion-closure position following total knee arthroplasty" North Carolina Orthopaedic Association Annual Meeting, Myrtle Beach, SC 1996.
  • "Thrombin inhibitory activity and in vivo clearance of polyethylene glycol - hirudin complex" Nineteenth annual Alpha Omega Alpha symposium, Duke University Medical Center . April 12, 1988 .
  • Fellow, American Academy of Orthopaedic Surgeons, February 2003.
  • Board Certified, American Board of Orthopaedic Surgery, September 2001.
  • U.S. Navy Submarine Medical Officer, December 1992.
  • U.S. Navy Diving Medical Officer, December 1991.
  • "Top Doctors" for Hip and Knee Arthroplasty, Money magazine, Special Report, "The Best Health Care in America" Fall 2003.
  • Navy Commendation Medal, United States Navy, 1993.
  • Navy Achievement Medal, United States Navy, 1991.
  • Health Professions Scholarship, United States Navy, 1986 to 1989.
  • Outstanding Seniors Award, University of South Carolina, 1985.
  • Phi Beta Kappa, 1984.
  • University of South Carolina General Scholarship, 1981 to 1985.
  • University of South Carolina Alumni Association Scholarship, 1981 to 1985.
  • National Merit Scholar, 1981 to 1985.
  • State of North Carolina
  • State of South Carolina
  • Commonwealth of Virginia

Related News

Dr. Karegeannes Volunteer’s to Support Cub Scout Day Camp

 |  Community Involvement

Dr. James Karegeannes has volunteered as an on-call physician for Cub Scout Day Camp June 11-15. Our commitment to community involvement is reflected in this kind of service. We wish...